DesignCTPB - Design Clinical Trials with Potential Biomarker Effect

Applying 'CUDA' 'GPUs' via 'Numba' for optimal clinical design. It allows the user to utilize a 'reticulate' 'Python' environment and run intensive Monte Carlo simulation to get the optimal cutoff for the clinical design with potential biomarker effect, which can guide the realistic clinical trials.

Last updated 4 years ago

3.70 score 1 stars 5 scripts 169 downloads

iimi - Identifying Infection with Machine Intelligence

A novel machine learning method for plant viruses diagnostic using genome sequencing data. This package includes three different machine learning models, random forest, XGBoost, and elastic net, to train and predict mapped genome samples. Mappability profile and unreliable regions are introduced to the algorithm, and users can build a mappability profile from scratch with functions included in the package. Plotting mapped sample coverage information is provided.

Last updated 24 days ago

2.60 score 5 scripts 254 downloads

scAnnotate - An Automated Cell Type Annotation Tool for Single-Cell RNA-Sequencing Data

An entirely data-driven cell type annotation tools, which requires training data to learn the classifier, but not biological knowledge to make subjective decisions. It consists of three steps: preprocessing training and test data, model fitting on training data, and cell classification on test data. See Xiangling Ji,Danielle Tsao, Kailun Bai, Min Tsao, Li Xing, Xuekui Zhang.(2022)<doi:10.1101/2022.02.19.481159> for more details.

Last updated 9 months ago

2.00 score 4 scripts 206 downloads

glmpermu - Permutation-Based Inference for Generalized Linear Models

In practical applications, the assumptions underlying generalized linear models frequently face violations, including incorrect specifications of the outcome variable's distribution or omitted predictors. These deviations can render the results of standard generalized linear models unreliable. As the sample size increases, what might initially appear as minor issues can escalate to critical concerns. To address these challenges, we adopt a permutation-based inference method tailored for generalized linear models. This approach offers robust estimations that effectively counteract the mentioned problems, and its effectiveness remains consistent regardless of the sample size.

Last updated 9 months ago

1.00 score 227 downloads

bossR - Biomarker Optimal Segmentation System

The Biomarker Optimal Segmentation System R package, 'bossR', is designed for precision medicine, helping to identify individual traits using biomarkers. It focuses on determining the most effective cutoff value for a continuous biomarker, which is crucial for categorizing patients into two groups with distinctly different clinical outcomes. The package simultaneously finds the optimal cutoff from given candidate values and tests its significance. Simulation studies demonstrate that 'bossR' offers statistical power and false positive control non-inferior to the permutation approach (considered the gold standard in this field), while being hundreds of times faster.

Last updated 11 months ago

1.00 score 190 downloads